Checklist of markers of C. difficile severe disease* (1 or more of)
Other (e.g., on Xray, CT, colonoscopy)
*Severe disease should be treated from outset with vancomycin 125 mg qid AND you should consider an infectious diseases consult.
Other indications for vancomycin = unresponsive to treatment with metronidazole with >= 3 stools/24 hours after 3 days OR 2nd and subsequent relapses.
Source: Upcoming ASID guidelines on C. difficile (to be published in the MJA)